反应详情

To a stirred solution of 2-benzyloxy-4-fluoro-1-nitrobenzene (2.4 g, 10 mmol) in EtOH (20 mL) is added SnCl2 (9.45 g, 50 mmol) and the suspension is stirred at RT overnight. The solvent is removed under reduced pressure and the residue is adjusted to pH >8. The aqueous layer is extracted with EtOAc and the combined organic layers are washed with water and brine, then dried over MgSO4 and filtered. The solvent is removed under reduced pressure to give the product as a red oil.

1. customThe solvent is removed under reduced pressure
2. extractionThe aqueous layer is extracted with EtOAc
3. washthe combined organic layers are washed with water and brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customThe solvent is removed under reduced pressure