反应详情

1.00 g (3.17 mmol) of 5-(4-chlorophenyl)-4-(4-methoxyphenylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one from Example 55A, 0.80 g (3.17 mmol) of 2-chloro-N-[3-(trifluoromethyl)phenylmethyl]-acetamide and 0.88 g (6.33 mmol) of potassium carbonate are suspended in 20 ml of acetonitrile and heated under reflux for 8 hrs. The mixture is then concentrated in vacuo, and the residue taken up in water and extracted three times with ethyl acetate. The combined organic phases are concentrated and the residue purified by preparative HPLC [Method 12]. 1.07 g (64% of theory) of the target compound are thus obtained.

1. temperatureheated
2. temperatureunder reflux for 8 hrs
3. concentrationThe mixture is then concentrated in vacuo
4. extractionextracted three times with ethyl acetate
5. concentrationThe combined organic phases are concentrated
6. customthe residue purified by preparative HPLC [Method 12]
7. custom1.07 g (64% of theory) of the target compound are thus obtained