反应详情

2 parts of [(tetrahydro-2H-pyran-2-ylidene)methyl]triphenylphosphonium chloride and 1.2 parts of cyclohexanecarbaldehyde were combined in 45 parts of xylene. This suspension was maintained under a nitrogen atmosphere and was refluxed for about 4 hours until a clear solution formed. After cooling the solution to room temperature, xylene was removed at a temperature of about 60° C. and under reduced pressure, leaving a product mixture. This mixture was separated chromatographically on a silica column using as the elution solvent 50 percent by volume of Skelly B in benzene, to yield 1-cyclohexyl-7-chloro-1-hepten-3-one.

1. temperatureThis suspension was maintained under a nitrogen atmosphere
2. temperaturewas refluxed for about 4 hours until a clear solution
3. customformed
4. customxylene was removed at a temperature of about 60° C. and under reduced pressure
5. customleaving a product mixture
6. customThis mixture was separated chromatographically on a silica column