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HRID68404

反应详情

EQUATION

反应方程式

HRID 68404 的结构方程式

REACTANTS

反应物

2
结构：C[C@H]1C[C@@H](CO)[C@](N)(c2cccc(C#N)c2)CO1
HCID86721298

未命名化合物

结构：C[C@H]1C[C@@H](CO)[C@](NC(=S)NC(=O)c2ccccc2)(c2cc(C#N)ccc2Cl)CO1
HCID86721302

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1C[C@@H](CO)[C@](NC(=S)NC(=O)c2ccccc2)(c2cccc(C#N)c2)CO1
HCID86721301

未命名化合物

PROCEDURE

实验过程

3-[(3S,4R,6S)-3-Amino-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]benzonitrile (C22) was converted to the product using the method described for the synthesis of N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide (C19) in Example 6. The resulting product was used in the next step without further purification. Yield: 118 mg, 0.288 mmol, 68%. LCMS m/z 410.2 [M+H+].

WORKUP

后处理

  1. customThe resulting product was used in the next step without further purification