HRID68405

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H]1C[C@@H](CO)[C@](NC(=S)NC(=O)c2ccccc2)(c2cccc(C#N)c2)CO1

HCID86721301

未命名化合物

结构：C[C@H]1C[C@H]2CSC(NC(=O)c3ccccc3)=N[C@@]2(c2cc(C#N)ccc2Cl)CO1

HCID86762644

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1C[C@H]2CSC(NC(=O)c3ccccc3)=N[C@@]2(c2cccc(C#N)c2)CO1

HCID86762643

未命名化合物

PROCEDURE

实验过程

N-{[(3S,4R,6S)-3-(3-Cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide (C23) was converted to the product using the method described for the synthesis of N-[(4aR,6S,8aS)-8a-(2-chloro-5-cyanophenyl)-6-methyl-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide (C20) in Example 6. The resulting product was used in the next step without further purification. Yield: 45.0 mg, 0.115 mmol, 40%. LCMS m/z 392.2 [M+H+].

WORKUP

后处理

customThe resulting product was used in the next step without further purification