反应详情

The desired compound was prepared according to the procedure of Example 1, step F, using N-hydroxy-4-[(3-methoxypropyl)amino]-1,2,5-oxadiazole-3-carboximidoyl chloride and 4-fluoro-3-(trifluoromethyl)benzeneamine as the starting materials in 87% yield. LCMS for C14H16F4N5O3 (M+H)+: m/z=378.1. 1H NMR (400 MHz, DMSO-d6): δ 11.5 (s, 1 H), 9.05 (s, 1 H), 7.30 (dd, J=10.0, 9.6 Hz, 1 H), 7.13-7.11 (m, 1 H), 7.05-7.00 (m, 1 H), 6.22 (t, J=5.7 Hz, 1 H), 3.35-3.32 (m, 2 H), 3.25-3.19 (m, 5 H), 1.79-1.72 (m, 2 H).