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HRID69892

反应详情

EQUATION

反应方程式

HRID 69892 的结构方程式

REACTANTS

反应物

4
结构：CCO
HCID702

Ethanol

C2H6O

结构：CCCCCCC
HCID8900

Heptane

C7H16

结构：CC(C)(C)OC(=O)N[C@@H]1CN(C(=O)OCc2ccccc2)CC[C@H]1O
HCID53487823

Benzyl (3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxypiperidine-1-carboxylate

C18H26N2O5

结构：CC(C)(C)OC(=O)N[C@H]1CN(C(=O)OCc2ccccc2)CC[C@@H]1O
HCID58423176

Phenylmethyl (3S,4S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-piperidinecarboxylate

C18H26N2O5

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)OCc2ccccc2)C[C@H]1O
HCID58745562

Benzyl (3R,4R)-4-[(tert-butoxycarbonyl)amino]-3-hydroxypiperidine-1-carboxylate

C18H26N2O5

PROCEDURE

实验过程

The enantiomerically pure (3S,4S)-benzyl 3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate and (3R,4R)-benzyl 3-(tert-butoxycarbonylamino)-4-hydroxypiperidine-1-carboxylate were resolved by chiral HPLC (For analysis Rt=6.8 min and 9.1 min respectively; n-heptane:ethanol=70:30 (v:v), Chiralpak AD-H prep 250×4.6 mm at 1 mL/min. For preparative separation, n-heptane:ethanol=80:20 (v:v), Chiralpak AS 50×500 mm at 90 mL/min).

WORKUP

后处理

  1. customFor analysis Rt=6.8 min and 9.1 min
  2. customFor preparative separation, n-heptane