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HRID703686

反应详情

EQUATION

反应方程式

HRID 703686 的结构方程式

REACTANTS

反应物

3
结构：CCOCC
HCID3283

Diethyl Ether

C4H10O

结构：CC(C)(C)[Si](C)(C)Cl
HCID28928

Chloro(1,1-dimethylethyl)dimethylsilane

C6H15ClSi

结构：CCCCCCCCCCC[C@@H]1C[C@H](O)[C@H](CCCCCC)C(=O)O1
HCID11013671

(3S,4S,6R)-3-Hexyl-4-hydroxy-6-undecyloxan-2-one

C22H42O3

PRODUCTS

生成物

1
结构：CCCCCCCCCCC[C@@H]1C[C@H](O[Si](C)(C)C(C)(C)C)[C@H](CCCCCC)C(=O)O1
HCID22847451

未命名化合物

收率 63.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

PROCEDURE

实验过程

(1.O.d) 1.5 g of (3S,4S,6R)-tetrahydro-3-hexyl-4-hydroxy-6-undecyl-2H-pyran-2-one are dissolved in 8 ml of DMF. 0.85 g of t-butyldimethylchlorosilane in 4 ml of DMF are then added dropwise. The mixture is stirred for 48 hours. The reaction mixture is poured into 100 ml of ether and washed with 1N hydrochloric acid. The organic phase is dried, filtered and evaporated. The material obtained is chromatographed on silica gel. There are obtained 1.26 g of (3S,4S,6R)-tetrahydro-3-hexyl -4-[(t-butyldimethylsilyl)oxy-]6-undecyl-2H-pyran-2-one, MS: 411 (M+ -t-buytl),

WORKUP

后处理

  1. washwashed with 1N hydrochloric acid
  2. customThe organic phase is dried
  3. filtrationfiltered
  4. customevaporated
  5. customThe material obtained
  6. customis chromatographed on silica gel