反应详情

A solution of tetra-n-butylammonium fluoride in tetrahydrofuran (1 mL) was added to a solution of (5R)-5-[(E)-2-[5-(4-{[tert-butyl(dimethyl)silyl]oxy}butyl)-6-methoxypyridin-2-yl]-2-(4-tert-butylphenyl)ethenyl]-1-(2,4-dimethoxybenzyl)pyrrolidin-2-one (140 mg) in tetrahydrofuran (4 mL), and the mixture was stirred at room temperature for three hours. The solvent was evaporated from the reaction solution under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1→0:10) to give (5R)-5-{(E)-2-(4-tert-butylphenyl)-2-[5-(4-hydroxybutyl)-6-methoxypyridin-2-yl]ethenyl}-1-(2,4-dimethoxybenzyl)pyrrolidin-2-one as a colorless oil (101 mg, 86%).

1. customThe solvent was evaporated from the reaction solution under reduced pressure
2. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1→0:10)