反应详情

An (R,S) mixture of the title compound was obtained as a colorless amorphous (240 mg) by performing substantially the same reaction as in Examples 1-16(2)(3) and 4-209 and 4-210(2)(3) sequentially except for using (5R)-5-[2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-2-(5-chloro-6-methoxypyridin-2-yl)ethenyl]pyrrolidin-2-one obtained in Example 4-48(1) and using ethyl iodide in place of methyl iodide. This was separated by chiral HPLC (CHIRALCEL OD-H, 40° C., flow rate: 7 mL/min, ethanol:hexane=0:100) to give one diastereomer (A) of the title compound as a colorless amorphous (38 mg) and the other diastereomer (B) of the title compound as a colorless amorphous (35 mg).

1. customwas obtained as a colorless amorphous (240 mg)
2. customthe same reaction as in Examples 1-16(2)(3) and 4-209 and 4-210(2)(3) sequentially except
3. customThis was separated by chiral HPLC (CHIRALCEL OD-H, 40° C., flow rate: 7 mL/min, ethanol:hexane=0:100)