HRID707399

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID551541

2-Bromo-4-methylthiazole

C4H4BrNS

结构：CC(C)(C)OC(=O)N[C@H]1C[C@H](N2C(=O)C(C)(C)c3cccnc32)C1

HCID178454100

未命名化合物

2 次

PRODUCTS

生成物

结构：Cc1csc(N[C@H]2C[C@H](N3C(=O)C(C)(C)c4cccnc43)C2)n1

HCID178431963

未命名化合物

PROCEDURE

实验过程

3,3-Dimethyl-1-(trans-3-((4-methylthiazol-2-yl)amino)cyclobutyl)-1 h-pyrrolo[2,3-b]pyridin-2(3h)-one was prepared by Method B7 using starting materials 1-(trans-3-aminocyclobutyl)-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one hydrochloride (intermediate 26, 0.100 g, 0.329 mmol) and 2-bromo-4-methylthiazole (0.0585 g, 0.329 mmol) at 120° C. for 96 h. M+1: 329.1. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.38 (s, 6 H) 2.25 (s, 3 H) 2.33-2.42 (m, 2 H) 3.38-3.49 (m, 2 H) 4.35 (br. s., 1 H) 5.27 (quin, J=8.56 Hz, 1 H) 5.60 (br. s., 1 H) 6.09 (s, 1 H) 6.96 (t, J=6.16 Hz, 1 H) 7.43 (d, J=6.85 Hz, 1 H) 8.17 (d, J=5.30 Hz, 1 H).

WORKUP

后处理

customat 120° C.
customfor 96 h