HRID707400

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21788840

2-Chloro-5-phenyl-1,3-thiazole

C9H6ClNS

结构：CC(C)(C)OC(=O)N[C@H]1C[C@H](N2C(=O)C(C)(C)c3cccnc32)C1

HCID178454100

未命名化合物

2 次

PRODUCTS

生成物

结构：CC1(C)C(=O)N([C@H]2C[C@H](Nc3ncc(-c4ccccc4)s3)C2)c2ncccc21

HCID178429383

未命名化合物

PROCEDURE

实验过程

3,3-Dimethyl-1-(trans-3-((5-phenylthiazol-2-yl)amino)cyclobutyl)-1H-pyrrolo[2,3-b]pyridin-2(3h)-one was prepared by Method B7 using starting materials 1-(trans-3-aminocyclobutyl)-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one hydrochloride (intermediate 26, 0.100 g, 0.329 mmol) and 2-chloro-5-phenylthiazole (0.0643 g, 0.329 mmol) at 120° C. for 96 h. M+1: 391.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.31 (s, 6 H) 2.31-2.40 (m, 2 H) 3.21-3.31 (m, 2 H) 4.34-4.43 (m, 1 H) 5.17 (quin, J=8.46 Hz, 1 H) 7.08 (dd, J=7.24, 5.09 Hz, 1 H) 7.17-7.22 (m, 1 H) 7.35 (br. t, J=7.70, 7.70 Hz, 2 H) 7.45 (br. d, J=7.20 Hz, 2 H) 7.52 (s, 1 H) 7.76 (dd, J=7.24, 1.56 Hz, 1 H) 8.21 (dd, J=5.28, 1.56 Hz, 1 H) 8.30 (d, J=6.20 Hz, 1 H).

WORKUP

后处理

customat 120° C.
customfor 96 h