反应详情

3,3-Dimethyl-1-(trans-3-((5-methylthiazol-2-yl)amino)cyclobutyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one was prepared by Method B7 using starting materials 1-(trans-3-aminocyclobutyl)-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one hydrochloride (intermediate 26, 0.100 g, 0.329 mmol) and 2-bromo-5-methylthiazole (0.0585 g, 0.329 mmol) at 120° C. for 192 h. M+1: 329.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.31 (s, 6 H) 2.23 (d, J=1.17 Hz, 3 H) 2.24-2.33 (m, 2 H) 3.16-3.27 (m, 2 H) 4.23-4.33 (m, 1 H) 5.14 (quin, J=8.41 Hz, 1 H) 6.71 (br. d, J=1.20 Hz, 1 H) 7.08 (dd, J=7.24, 5.28 Hz, 1 H) 7.76 (dd, J=7.24, 1.56 Hz, 1 H) 7.81 (d, J=6.26 Hz, 1 H) 8.21 (dd, J=5.18, 1.66 Hz, 1 H).

1. customat 120° C.
2. customfor 192 h