反应详情

At RT, 280 mg (0.74 mmol) of the compound of Example 7A together with 108 mg (0.89 mmol) of 4-N,N-dimethylaminopyridine were initially charged in 5.3 ml of pyridine, 0.31 ml (1.84 mmol) of trifluoromethanesulphonic anhydride were added a little at a time and the mixture was stirred for 12 h. The pyridine was then removed on a rotary evaporator. The residue was taken up in acetonitrile and 1 N hydrochloric acid and purified by preparative HLPC [Method 9]. This gave 230 mg (86% of theory) of the title compound.

1. customThe pyridine was then removed on a rotary evaporator
2. custom1 N hydrochloric acid and purified by preparative HLPC [Method 9]