反应详情

When tert-butyl 5-ethynyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate was substituted for 1-octyne and the product of Step B was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 48% yield, as a light yellow paste. 1H-NMR (CDCl3) 1.43 (s, 3H); 1.46 (s, 9H); 1.49 (s, 3H); 3.84 (s, 6H); 3.9 (s, 3H); 3.91 (s, 3H); 4.00 (d, 2H, J=11.34 Hz); 4.1 (d, 2H, J=11.35 Hz); 5.08 (s, 2H); 5.19 (s, 1H); 6.95 (d, 1H, J=2.04 Hz); 7.00 (dd, 1H, J=2.18, 8.75 Hz); 7.11 (s, 2H); 7.3 (d, 2H, J=8.5 Hz); 7.35 (d, 2H, J=8.49 Hz); 7.74 (s, 1H); 8.25 (d, 1H, J=8.7 Hz).