反应详情

When the product of Step D was substituted for 1-octyne and tert-butyl-5-((4-iodophenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 90% yield, as a light yellow paste. 1H-NMR (CDCl3) 1.44 (s, 3H); 1.47 (s, 9H); 1.49 (s, 3H); 3.85 (s, 3H); 4.02 (d, 2H, J=11.34 Hz); 4.09 (d, 2H, J=11.38 Hz); 5.20 (s, 1H); 6.88 (dd, 1H, J=2.24, 8.6 Hz); 6.93 (s, 1H); 6.96 (d, 1H, J=1.97 Hz); 7.38-7.41 (m, 3H); 7.46 (d, 2H, J=8.44 Hz).