tert-Butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((4-(5-(2-methylbenzofuran-5-yl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)propane-1,3-diol

HRID 710397Notes

Reaction equation

CC1(C)[O:7][CH2:6][C:5]([NH:33]C(=O)OC(C)(C)C)([CH2:8][N:9]2[C:17]3[C:12](=[C:13]([C:18]4[N:22]=[C:21]([C:23]5[CH:24]=[CH:25][C:26]6[O:30][C:29]([CH3:31])=[CH:28][C:27]=6[CH:32]=5)[O:20][N:19]=4)[CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10]2)[CH2:4][O:3]1.C(OC1C=C(C2ON=C(C3C=CC=C4C=3CCN4CC3(NC(=O)OC(C)(C)C)COC(C)(C)OC3)N=2)C=CC=1OCC)C>>[NH2:33][C:5]([CH2:8][N:9]1[C:17]2[C:12](=[C:13]([C:18]3[N:22]=[C:21]([C:23]4[CH:24]=[CH:25][C:26]5[O:30][C:29]([CH3:31])=[CH:28][C:27]=5[CH:32]=4)[O:20][N:19]=3)[CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1)([CH2:4][OH:3])[CH2:6][OH:7]

Participants

Reactant 2

HCID 66726782tert-Butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate

HCID 86661792tert-Butyl 2,2-dimethyl-5-((4-(5-(2-methylbenzofuran-5-yl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-1,3-dioxan-5-ylcarbamate

Product 1

HCID 461950292-Amino-2-((4-(5-(2-methylbenzofuran-5-yl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)propane-1,3-diolYield 67%

Procedure

When the product of Step F was substituted for tert-butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 34, Step E, the identical process afforded the title compound in 67% yield., as a colourless foam. 1H-NMR (DMSO-d6) 1.36 (broad s, 3H); 2.91 (s, 2H); 3.29 (m, 2H+H2O); 3.55 (tr, 2H, J=8.02 Hz); 4.55 (m, 2H); 6.75-6.79 (m, 2H); 7.14 (tr, 1H, J=7.9 Hz); 7.26 (d, 1H, 7.8 Hz); 7.72 (d, 1H, J=8.5 Hz); 8.02 (d, 1H, J=9.17 Hz); 8.36 (s, 1H).

Sources & evidence

ORD record: ord-df62c29f0107490ba50b2597fdddda78
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09181182B2

Reaction notes

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