反应详情

When product of Step B was substitute for tert-butyl 5-((3-(1-admantyl)-4-(octyloxy)phenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 63 Step C, the similar process afforded the title compound in 71% yield, as a colourless solid. 1H-NMR (CDCl3) 1.70 (s, 6H); 1.88-1.94 (m, 2H); 2.0 (broad s, 3H); 2.1 (broad s, 6H); 2.58-2.64 (m, 2H); 3.63 (d, 2H, J=12 Hz); 3.69 (d, 2H, J=12.08 Hz); 6.69 (d, 1H, J=8.18 Hz); 7.13-7.16 (m, 3H); 7.3 (d, 1H, J=2.06 Hz); 7.37 (d, 2H, J=8.07 Hz).