反应详情

When the product of Step E was substituted for tert-butyl 2,2-dimethyl-5-((4-(5-(6-propylpyridin-3-yl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-1,3-dioxan-5-ylcarbamate in Example 66 Step F, the identical process afforded the title compound in 45% yield, as colourless solid. 1H-NMR (CDCl3+CD3OD) 0.89 (tr, 3H, J=7.4 Hz); 1.55-1.68 (m, 2H); 1.88 (m, 2H); 2.61 (tr, 2H, J=7.4 Hz); 2.95-3.1 (m, 8H+H2O); 3.31 (m, 4H); 3.35-3.79 (m, 4H); 7.06-7.16 (m, 3H); 7.23-7.29 (m, 2H+CDCl3); 8.02 (d, 2H, J=8 Hz).