反应详情

The compound was synthesized starting from benzimidazol-5-carbohydrazide (176 mg; 1 mmol), TEA (0.153 ml; 1.1 mmol), 2,3-dimethoxyphenylpropionylchloride (228 mg, 1.1 mmol) and Lawesson's reagent (606 mg; 1.5 mmol) as described in method 1; yield: 0.025 g (6.8%); MS m/z: 367.2 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.07 (t, 2H, 3J=7.9 Hz); 3.38 (t, 2H, 3J=7.9 Hz); 3.73 (s, 3H); 3.79 (s, 3H); 6.84 (dd, 1H, 4J=1.7 Hz, 3J=8.3 Hz); 6.91 (dd, 1H, 4J=1.7 Hz, 3J=8.3 Hz); 6.98 (t, 1H, 3J=8.3 Hz); 7.71 (d, 1H, 3J=8.3 Hz); 7.77 (dd, 1H, 4J=1.7 Hz, 3J=8.3 Hz); 8.12 (d, 1H, 4J=1.7 Hz); 8.37 (s, 1H); HPLC (METHOD [A]): rt 12.03 min (95.8%)

1. customThe compound was synthesized
2. customrt 12.03 min (95.8%)