反应详情

The compound was from prepared from 4-chlorophenylacetic acid and 1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine using General Method A. The product mixture was crystallized from 4:1 CH3CN:H2O to give the title compound as an off-white crystalline solid (37.6 mg). 1H NMR (400 MHz, MeOD-d4, mixture of rotamers) δ 8.18 (s, 0.9H), 7.84 (s, 0.1H), 7.56 (m, 2H), 7.25-7.37 (m, 6H), 4.02 (s, 0.2H), 3.92 (s, 1.8H), 2.81 (t, J=6.2 Hz, 2H), 2.49 (m, 2H), 1.90 (m, 2H); MS: (ES) m/z calculated for C20H18ClFN3O [M+H]+ 370.1, found 370.1.

1. customThe product mixture was crystallized from 4:1 CH3CN