反应详情

To 2-{(8R)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]-8-(3,4,5-trifluorophenoxy)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol monophosphate (213.4 g) was added ethanol (350 mL), the mixture was dissolved at 60° C., and the insoluble material was removed by filtration. 2-Propanol (700 mL) was added to the filtrate at 60° C., and the mixture was stirred for 30 min, and at 0° C. for 30 min. The crystals were collected by filtration, washed with 2-propanol (250 mL) and dried at 60° C. under reduced pressure to give the title compound (184 g).

1. dissolutionthe mixture was dissolved at 60° C.
2. customthe insoluble material was removed by filtration
3. addition2-Propanol (700 mL) was added to the filtrate at 60° C.
4. waitat 0° C. for 30 min
5. filtrationThe crystals were collected by filtration
6. washwashed with 2-propanol (250 mL)
7. customdried at 60° C. under reduced pressure