反应详情

To a stirred suspension of (R)-3,3,6,6-tetramethyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one (D35) (714 mg, 3.89 mmol) in MeOH (15 ml), p-TSA (74 mg, 0.39 mmol) was added and the resulting mixture was heated at reflux for 2 hrs. Solvent was evaporated off and the residue was loaded on SPE-SCX cartridge (5 g). The cartridge was washed with MeOH (3 column volume). The methanolic phase was collected and evaporated to afford the title compound (D36) (690 mg)

1. additionwas added
2. temperaturethe resulting mixture was heated
3. temperatureat reflux for 2 hrs
4. customSolvent was evaporated off
5. washThe cartridge was washed with MeOH (3 column volume)
6. customThe methanolic phase was collected
7. customevaporated