反应详情

The title compound (22 mg, 0.044 mmol) was prepared following the general procedure of Example 1 from [4-(4-methoxy-benzoyl)-piperidin-1-yl]-acetic acid (65 mg, 0.188 mmol, 1.0 eq) and 2-[(2-methoxy-ethylamino)-methyl]-3,5,7,8tetrahydro-pyrano[4,3-d]pyrimidin-4-one (51.7 mg, 0.188 mmol, 1.0 eq). 1H NMR (400 MHz, DMSO-d6) δ ppm 7.88-8.02 (m, 2H) 6.98-7.10 (m, 2H) 4.52 (br s, 1H) 4.36 (d, J=16.67 Hz, 3H) 3.75-3.92 (m, 5H) 3.52-3.58 (m, 3H) 3.42-3.45 (m, 3H) 3.27 (d, J=5.05 Hz, 15H) 3.17 (br s, 2H). HR-MS (m/z, MH+): 499.2580, 500.2607, 501.2628. HPLC retention time: 2.62 min (Ascentis column 3.0×100 mm 3 um C18 column; flow rate of 1.0 mL/min with gradient from 5% to 95% acetonitrile in 10 min, 0.1% FA).