反应详情

Finally, a reaction flask was charged with Compound F in MeOH (10 vol) at 20-25° C. then treated with 2N HCl/Et2O (˜2 mL, 2.0 equiv) and stirred for 12 h. The reaction mixture was concentrated to dryness and the resulting solid was dissolved in water/EtOAc. The aqueous portion was neutralized then extracted with CH2Cl2. The combined organic layers were dried with MgSO4 then concentrated to provide (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine (Compound B).

1. concentrationThe reaction mixture was concentrated to dryness
2. dissolutionthe resulting solid was dissolved in water/EtOAc
3. extractionThe aqueous portion was neutralized then extracted with CH2Cl2
4. dry with materialThe combined organic layers were dried with MgSO4
5. concentrationthen concentrated