反应详情

Following the procedure as describe in preparation of Example 5, variations as required to replace benzoyl chloride with 4-(trifluoromethy)benzoyl chloride to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(4-trifluoromethylbenzoylamino)-isonicotinamide was obtained in 60% yield: mp 181-183° C.; 1H NMR (300 MHz, CDCl3) δ 8.92 (br s, 1H), 8.61 (s, 1H), 8.32 (d, J=4.3 Hz, 1H), 7.97 (d, J=7.8 Hz, 2H), 7.73 (d, J=7.8 Hz, 2H), 7.53 (d, J=4.3 Hz, 1H), 7.38-7.15 (m, 5H), 6.98 (br s, 1H), 4.63 (d, J=5.7 Hz, 2H); MS (ES+) m/z 400.4 (M+1).

1. customas describe in preparation of Example 5, variations