反应详情

Following the procedure as describe in Example 6, making variations as required to replace 2-fluorobenzoyl chloride with thiophene-2-carbonyl chloride to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(thiophene-2-carboxamido)isonicotinamide was obtained as a colorless solid in 73% yield: mp 160-162° C. (hexanes/ethyl acetate); 1H NMR (300 MHz, CDCl3) δ 11.07 (s, 1H), 9.32 (t, J=5.7 Hz, 1H), 8.53-8.47 (m, 2H), 8.23-8.22 (m, 1H), 7.87 (d, J=5.0 Hz, 1H), 7.58-7.48 (m, 1H), 7.31-7.37 (m, 6H), 4.46 (d, J=5.9 Hz, 2H); MS (ES+) m/z 338.5 (M+1).