反应详情

Following the procedure as described in Example 10, making variations as required to replace N-(4-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide with N-(4-(4-propyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide, N-(4-(4-propyl-1H-imidazol-2-yl)pyridin-2-yl)benzamide was obtained as a colorless solid in 35% yield: mp 95-97° C.; 1H NMR (300 MHz, CDCl3) δ 9.16 (br s, 1H), 8.69 (s, 1H), 8.11 (d, J=5.3 Hz, 1H), 7.88-7.82 (m, 2H), 7.70 (dd, J=5.3, 1.4 Hz, 1H), 7.56-7.49 (m, 1H), 7.48-7.37 (m, 2H), 6.87 (s, 1H), 2.54 (t, J=7.4 Hz, 2H), 1.69-1.55 (m, 2H), 0.90 (t, J=7.4 Hz, 3H); MS (ES+) m/z 307.3 (M+1).