反应详情

Following the procedure as described in Example 10, making variations as required to replace N-(4-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide with N-(4-(4-(3,5-difluorobenzyl)-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide, N-(4-(4-(3,5-difluorobenzyl)-1H-imidazol-2-yl)pyridin-2-yl)benzamide was obtained as a colorless solid in 32% yield: 1H NMR (300 MHz, CDCl3) δ 8.98 (br s, 1H), 8.67 (s, 1H), 8.22 (d, J=3.6 Hz, 1H), 7.88-7.81 (m, 2H), 7.73 (d, J=4.8 Hz, 1H), 7.61-7.40 (m, 3H), 6.82 (s, 1H), 6.78-6.70 (m, 1H), 6.66-6.57 (m, 2H), 3.94 (s, 2H); MS (ES+) m/z 391.1 (M+1).