反应详情

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with (1-methyl-1H-pyrazol-3-yl)methanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((1-methyl-1H-pyrazol-3-yl)methyl)isonicotinamide was obtained as a colorless solid in 30% yield: mp 79-81° C.; 1H NMR (300 MHz, CDCl3) δ 8.57 (s, 1H), 8.33 (d, J=5.1 Hz, 1H), 7.37 (dd, J=5.1 Hz, 1.2 Hz, 1H), 7.27-7.22 (m, 3H), 7.03-6.91 (m, 3H), 6.19 (d, J=2.1 Hz, 1H), 4.60 (d, J=5.1 Hz, 2H), 4.41 (s, 2H), 4.02 (t, J=8.1 Hz, 2H), 3.84 (s, 3H), 3.34 (t, J=8.1 Hz, 2H); MS (ES+) m/z 408.8 (M+1).