反应详情

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with (2-(trifluoromethyl)thiazol-4-yl)methanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((2-(trifluoromethyl)thiazol-4-yl)methyl)isonicotinamide was obtained as a colorless solid in 30% yield: mp 66-68° C.; 1H NMR (300 MHz, CDCl3) δ 8.68 (s, 1H), 8.36 (d, J=5.1 Hz, 1H), 7.59 (s, 1H), 7.35 (d, J=5.1 Hz, 1H), 7.28-7.20 (m, 2H), 7.17-6.99 (m, 3H), 4.78 (d, J=6.0 Hz, 2H), 4.43 (s, 2H), 4.03 (t, J=8.0 Hz, 2H), 3.37 (t, J=8.0 Hz, 2H); MS (ES+) m/z 479.8 (M+1).