反应详情

6-(5-(t-Butyldimethylsilyloxy)pentan-2-yl)-4-hydroxy-3-propionyl-2-H-pyran-2-one (IV in Scheme 1; Example 1.3; 3 g; 8.15 mmol) in 100 ml AcOH/THF/water (3/1/1, v/v/v) was stirred for 18 h at 25° C. The reaction mixture was neutralized with saturated NaHCO3, extracted with 3×50 ml EtOAc, dried with anhydrous Na2SO4, and evaporated to an oil. The product was purified via silica chromatography (40% EtOAc in hexanes).

1. extractionextracted with 3×50 ml EtOAc
2. dry with materialdried with anhydrous Na2SO4
3. customevaporated to an oil
4. customThe product was purified via silica chromatography (40% EtOAc in hexanes)