反应详情

To a solution of tert-butyl 4-((4-((3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl)pyrimidin-2-yl)amino)-2-ethoxybenzoate (40 mg) obtained in Step D of Example 139 in ethyl acetate (4.0 mL) was added a solution of 4 M hydrogen chloride in ethyl acetate (4.0 mL), the mixture was stirred at room temperature for 2 hr, and the solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (20 mg).

1. customthe solvent was evaporated under reduced pressure
2. washThe residue was washed with ethyl acetate