Phosphorus pentachloride → 3-chloro-7-fluoro-5-methylisoquinolin-1(2H)-one

To a solution of 6-fluoro-2-(hydroxyimino)-4-methyl-2,3-dihydro-1H-inden-1-one (800 mg, 4.12 mmol) in anhydrous CCl4 (100 mL) was added PCl5 (1.28 g, 6.18 mmol) and stirred at RT for 16 h. The reaction mixture was concentrated in vacuo and the residue dissolved in anhydrous 1,4-dioxane (100 mL), cooled 0° C., the solution was saturated with HCl gas and allowed to stir RT for 16 h. The reaction mixture was heated at 60° C. for 2 h, cooled to RT and diluted with EtOAc (50 mL), washed with water (25 mL), saturated NaHCO3 solution (25 mL), brine solution (25 mL), dried (Na2SO4), filtered and concentrated in vacuo. The crude material was washed with diethyl ether (10 mL), n-pentane (10 mL) and was dried in vacuo to obtain 3-chloro-7-fluoro-5-methylisoquinolin-1(2H)-one as a pale yellow solid (550 mg, 68%).

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionthe residue dissolved in anhydrous 1,4-dioxane (100 mL)
3. temperaturecooled 0° C.
4. stirringto stir RT for 16 h
5. temperatureThe reaction mixture was heated at 60° C. for 2 h
6. temperaturecooled to RT
7. additiondiluted with EtOAc (50 mL)
8. washwashed with water (25 mL), saturated NaHCO3 solution (25 mL), brine solution (25 mL)
9. dry with materialdried (Na2SO4)
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. washThe crude material was washed with diethyl ether (10 mL), n-pentane (10 mL)
13. customwas dried in vacuo

ORD record

ord-6d2dcf20b87a497fa591616599036dc8

Source dataset

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09193689B2