Ethyl 2-(4-(2-(6-methoxy-2,3-dihydrobenzofuran-2-yl)ethyl)phenoxy)acetate → 2-((4-(5-(((4-Fluorophenyl)(isopropyl)amino)methyl)thiophen-2-yl)benzyl)(methyl)amino)ethanol
반응식
C[O:2][C:3](=O)[CH2:4][N:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[S:15][C:16]([CH2:19][N:20]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)[CH:21]([CH3:23])[CH3:22])=[CH:17][CH:18]=2)=[CH:10][CH:9]=1)[CH3:6].C(OC(=O)COC1C=CC(CCC2CC3C=CC(OC)=CC=3O2)=CC=1)C>>[F:30][C:27]1[CH:26]=[CH:25][C:24]([N:20]([CH2:19][C:16]2[S:15][C:14]([C:11]3[CH:12]=[CH:13][C:8]([CH2:7][N:5]([CH3:6])[CH2:4][CH2:3][OH:2])=[CH:9][CH:10]=3)=[CH:18][CH:17]=2)[CH:21]([CH3:23])[CH3:22])=[CH:29][CH:28]=1참가 물질
3
실험 절차
When the product of Step C was substituted for ethyl-2-(4-(2-(6-methoxy-2,3-dihydrobenzofuran-2-yl)ethyl)phenoxy)acetate in Example 21, Step D, the similar process afforded the title compound in 28% yield, as light yellow paste. 1H NMR (CDCl3) 7.47 (d, 2H, J=8.05 Hz); 7.24 (d, 2H, J=8.04 Hz); 7.10 (d, 1H, J=3.60 Hz); 6.91-6.85 (m, 3H); 6.81-6.76 (m, 2H); 4.44 (s, 2H); 4.07-3.98 (m, 1H); 3.61 (t, 2H, J=5.31 Hz); 3.53 (s, 3H); 2.58 (t, 2H, J=5.31 Hz); 2.21 (s, 3H); 1.21 (d, 6H, J=6.56 Hz).
출처 및 근거
- ORD 기록
- ord-fe8806905fcc436aa24a08d816c76517
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09193716B2
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