反应详情

3a,6a-Dihydro-thieno[3,2-b]thiophene-2-carboxylic acid methoxy-methyl-amide (1.955 g, 8.60 mmol) was dissolved in THF. The stirred solution was cooled to 0° C. before methylmagnesium bromide (1.4 M in PhMe, 8.6 mL, 12.04 mmol) was added. The reaction was allowed to gradually warm to RT o/n, then it was quenched by addition of 10% HCl. The aqueous phase was extracted with diethyl ether. The organic phase was washed with brine then dried over MgSO4, filtered and concentrated to afford the title compound (1.98 g, 80%).

1. additionwas added
2. customwas quenched by addition of 10% HCl
3. extractionThe aqueous phase was extracted with diethyl ether
4. washThe organic phase was washed with brine
5. dry with materialthen dried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated