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HRID72162

反应详情

EQUATION

反应方程式

HRID 72162 的结构方程式

REACTANTS

反应物

2
结构：Cl.NC[C@@H](O)CP(=O)(CC1CCCCC1)OCc1ccccc1
HCID68622110

未命名化合物

结构：CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)O
HCID90473044

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)NC[C@@H](O)CP(=O)(O)CC1CCCCC1
HCID11584435

未命名化合物

PROCEDURE

实验过程

The title compound was prepared substantially following the procedures as set forth in Method B, Example 12, and employing ((R)-3-amino-2-hydroxy-propyl)-cyclohexylmethyl-phosphinic acid benzyl ester hydrochloride and N-Cbz-Trp-Val-OH as the staring materials, which yielded the title compound as a white powder. 1H NMR (CD3OD, 300 MHz): δ 7.65-7.62 (d, 1H), 7.38-7.35 (d, 1H), 7.17-7.01 (m, 3H), 4.26-4.20 (m, 1H), 4.17-4.14 (d, 1H), 4.05 (m, 1H), 3.46-3.20 (m, 4H), 2.00 (m, 1H), 1.9-1.88 (m, 2H), 1.77-1.54 (m, 8H), 1.34-1.16 (m, 3H), 1.05-0.94 (m, 8H). 31P NMR (CD3OD, 300 MHz): δ 42.89. LCMS m/z: [M+H]+=521.

WORKUP

后处理

  1. customThe title compound was prepared substantially