huagongshe.com
HRID72163

反应详情

EQUATION

反应方程式

HRID 72163 的结构方程式

REACTANTS

反应物

2
结构：CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)C(=O)O
HCID6992485

未命名化合物

结构：Cl.NC[C@@H](O)CP(=O)(CC1CCCCC1)OCc1ccccc1
HCID68622110

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC[C@@H](O)CP(=O)(O)CC1CCCCC1
HCID11526150

未命名化合物

PROCEDURE

实验过程

The title compound was prepared substantially following the procedures as set forth in Method B, Example 12, and employing ((R)-3-amino-2-hydroxy-propyl)-cyclohexylmethyl-phosphinic acid benzyl ester hydrochloride and N-Cbz-Tyr-Val-OH as the starting materials, which yielded the title compound as a white powder. 1H NMR (CD3OD, 300 MHz): δ 7.06 (d, 2H), 6.75 (d, 2H), 4.15-4.06 (m, 2H), 3.18-3.10 (m, 2H), 3.0-2.9 (m, 1H), 2.09-2.02 (m, 1H), 1.92-1.88 (m, 2H), 1.86-1.61 (m, 6H), 1.56-1.50 (m 3H), 1.30-1.17 (m, 4H), 1.06-0.95 (m, 8H). 31P NMR (CD3OD, 300 MHz): δ 41.72. LCMS m/z: [M+H]+=498.

WORKUP

后处理

  1. customThe title compound was prepared substantially