反应详情

温度

60 °C

A suspension of 1.14 g (2.05 mmol) of (7R,8R,9R)-10-acetyl-3,9-diphenyl-7-(2-methoxyethoxy)-2-methyl-8-pivaloyloxy-7.8.9.10-tetrahydroimidazo[1.2-h][1.7]naphthyridine and 2.28 g (16.5 mmol) potassium carbonate in aminoethanol is stirred at 60° C. for 4 h. The reaction is quenched by adding of saturated aqueous ammonium chloride solution. Subsequently the mixture is extracted twice with ethyl acetate. The combined organic layers are washed with brine, dried over sodium sulphate and evaporated in vacuo. The crude product is purified by column chromatography (diethyl ether/petrol ether: 7/3) to give 0.52 g (1.21 mmol/60%) of the title compound as a colourless solid with a melting point of 190–192° C. (diethyl ether).

1. customThe reaction is quenched
2. additionby adding of saturated aqueous ammonium chloride solution
3. extractionSubsequently the mixture is extracted twice with ethyl acetate
4. washThe combined organic layers are washed with brine
5. dry with materialdried over sodium sulphate
6. customevaporated in vacuo
7. customThe crude product is purified by column chromatography (diethyl ether/petrol ether: 7/3)