反应详情

A solution of 5-methoxybenzo[b]thiophene (0.33 g) in THF (8 ml) was cooled to −78° C., and an n-butyl lithium hexane solution (1.6 M; 1.4 ml) was added dropwise to this solution. The mixture was stirred for 1 h at the same temperature, and a solution of 5,6-dihydro-7H-pyrrolo[1,2-c]imidazol-7-one (0.18 g) in THF (3 ml) was added to this solution. The reaction mixture was stirred for 1 h at the same temperature, and saturated brine was added. The mixture was warmed to room temperature and the organic layer was separated. The organic layer was diluted with ethyl acetate, washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated. The residue was suspended in ethyl acetate and filtrated to give the title compound (0.24 g) as pale brown crystals. The crystals were recrystallized from THF to give the title compound (0.13 g) as colorless crystals.

1. additionwas added
2. customthe organic layer was separated
3. additionThe organic layer was diluted with ethyl acetate
4. washwashed with saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customThe solvent was evaporated
7. filtrationfiltrated