反应详情

0.8 g (2.41 mmol) of N-(3-trifluoromethyl-phenyl)-4-(N-oxido4-pyridyl)-2-pyrimidineamine is suspended in 40 ml of acetonitrile. 0.834 ml (6.65 mmol) of tri-methylsilyl cyanide and 0.611 ml (6.665 mmol) of dimethylcarbamoyl chloride are added and the reaction mixture is stirred for 12 hours at 60°. After concentration under reduced pressure, crystallisation is effected from tetrahydrofuran/diethyl ether. N-(3-trifluoromethyl-phenyl)-4-(2-cyano-4-pyridyl)-2-pyrimidineamine is obtained; m.p. 164°-166°, Rf =0.40 (n-hexane:ethyl acetate=1:1).

1. concentrationAfter concentration
2. customunder reduced pressure, crystallisation