HRID725852

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID14996960

未命名化合物

结构：CN(C)C(=O)C1CC(C(=O)OC(C)(C)C)NC1c1ccccc1

HCID86751897

未命名化合物

PRODUCTS

生成物

结构：Cc1cccc(NC(=O)NCC(=O)N2C(C(=O)OC(C)(C)C)CC(C(=O)N(C)C)C2c2ccccc2)c1

HCID86751896

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A The reaction is carried out in a way analogous to that described in Example 2B but from 1.7 g of tert-butyl (2RS,4RS,5SR)-4-dimethylcarbamoyl-5-phenylpyrrolidine-2-carboxylate, 1.15 g of 2-[3-(3-methylphenyl)ureido]acetic acid and 1.15 g of N,N'-dicyclohexylcarbodiimide in 50 cm3 of acetonitrile. After treatment, there are obtained 2.2 g of tert-butyl (2RS,4RS,5SR)-4-dimethylcarbamoyl-1-{2-[3-(3-methylphenyl)ureido]acetyl}-5-phenylpyrrolidine-2-carboxylate, melting at 199° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1898a1ece6cb42239d68cdd5aa597a39
来源数据集: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05707991
来源说明: uspto-grants-1998_01

反应 SMILES

[CH3:1][N:2]([CH3:23])[C:3]([CH:5]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:8][CH:7]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:6]1)=[O:4].[CH3:24][C:25]1[CH:26]=[C:27]([NH:31][C:32](=[O:38])[NH:33][CH2:34][C:35](O)=[O:36])[CH:28]=[CH:29][CH:30]=1.C1(N=C=NC2CCCCC2)CCCCC1>C(#N)C>[CH3:1][N:2]([CH3:23])[C:3]([CH:5]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:8]([C:35](=[O:36])[CH2:34][NH:33][C:32]([NH:31][C:27]2[CH:28]=[CH:29][CH:30]=[C:25]([CH3:24])[CH:26]=2)=[O:38])[CH:7]([C:16]([O:18][C:19]([CH3:20])([CH3:22])[CH3:21])=[O:17])[CH2:6]1)=[O:4]