反应详情

The reaction is carried out in a way analogous to that described in Example 2B, but from 1 g of tert-butyl (2RS,4RS,5SR)-4-cyano-5-phenylpyrrolidine-2-carboxylate, 0.76 g of 2-[3-(3-methylphenyl)ureido]acetic acid and 0.76 g of N,N'-dicyclohexylcarbodiimide in 50 cm3 of acetonitrile. After treatment, there are obtained 1.2 g of tert-butyl (2RS,4RS,5SR)-4-cyano-1-{2-[3-(3-methylphenyl)ureido]acetyl}-5-phenylpyrrolidine-2-carboxylate, melting at 150° C.