反应详情

First, 9 g of 2,3-difluoro-1-[trans-4-(4-ethoxycarbonyl-1-butenyl)cyclohexyl]benzene, 0.5 g of 10% Pd--C, and 50 ml of ethyl acetate were placed in a 300 ml autoclave. The mixture was stirred for 3 days under a hydrogen pressure of 30 kg/cm2. A catalyst was filtered away and a filtrate was concentrated. Thereafter, the residue was purified by silica gel column chromatography (eluent: toluene/hexane=1/1) to obtain 7.71 g of 2,3-difluoro-1-[trans-4-(4-ethoxycarbonylbutyl)cyclohexyl]benzene (Y: 85.1%). The compound thus obtained had a purity of 85% by GC.

1. filtrationA catalyst was filtered away
2. concentrationa filtrate was concentrated
3. customThereafter, the residue was purified by silica gel column chromatography (eluent: toluene/hexane=1/1)