反应详情

10 ml of trifluoroacetic acid, followed by liters of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 1050 mg of (2S,4S)-4-(4-methoxybenzylthio)-2-(4-methyl-1-piperazinylcarbonyl)-1-methylpyrrolidine [prepared as described in step (i) above] in 3 ml of anisole, and the resulting mixture was stirred at room temperature for 1 hour. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and the residue was triturated with diethyl ether to cause solidification. The solid was washed with diethyl ether five times and dried, to give 1350 mg of the title compound as a powder.

1. additionwere added, whilst ice-
2. concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
3. customthe residue was triturated with diethyl ether
4. washThe solid was washed with diethyl ether five times
5. customdried