反应详情

To a solution of tert-butyl (2S)-2-((3S)-3-{[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoate (1 g) in DMF (20 ml) was added potassium carbonate (0.92 g) and benzyl-2-bromoacetate (0.33 g), and the mixture was stirred under nitrogen at room temperature for 72 h. The reaction mixture was filtered, concentrated under reduced pressure, and the residue partitioned between water and DCM. The organic layer was isolated, dried (over magnesium sulphate and purified by SPE (silica, cyclohexane:ethyl acetate 2:1) to give the title compound (1.0 g) as a white solid.

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated under reduced pressure
3. customthe residue partitioned between water and DCM
4. customThe organic layer was isolated
5. dry with materialdried (over magnesium sulphate
6. custompurified by SPE (silica, cyclohexane:ethyl acetate 2:1)