5-Tetralinylamine → HCID 11661551, compound

HRID 729310Notes

Reaction equation

Cl[C:2]1[C:3](=[O:19])[N:4]([CH2:15][CH2:16][O:17][CH3:18])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:20]1([NH2:30])[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[CH:23]=[CH:22][CH:21]=1>>[CH3:18][O:17][CH2:16][CH2:15][N:4]1[C:3](=[O:19])[C:2]([NH:30][C:20]2[C:29]3[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=3[CH:23]=[CH:22][CH:21]=2)=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:5]1(=[O:14])=[O:13]

Participants

Reactant 2

HCID 166715-Tetralinylamine

HCID 672439094-Chloro-2-(2-methoxyethyl)-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 11661551HCID 11661551, compound

Procedure

The title compound was prepared from 4-chloro-2-(2-methoxyethyl)-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 5,6,7,8-tetrahydronaphthalen-1-amine in a similar manner as described for e.g. Examples 9 and 13. 1H NMR (400 MHz, CD3CN): δ 7.37 (bs, 1H), 7.20-7.15 (m, 1H), 7.11-7.01 (m, 4H), 6.75 (d, 1H), 6.70 (t, 1H), 6.63-6.60 (m, 1H), 3.90 (t, 2H), 3.72 (t, 2H), 3.38 (s, 3H), 2.60-2.54 (m, 4H), 1.76-1.69 (m, 2H), 1.66-1.59 (m, 2H); Mass Spectrum: M+H+ 413.

Sources & evidence

ORD record: ord-48fa2d0b6b904fc2925d615780894ee0
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582629B2

Reaction notes

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