Benzenamine, 4-(4-morpholinyl)- → 2-Ethyl-4-[(4-morpholin-4-ylphenyl)amino]-5-[4-(trifluoromethyl)phenyl]isothiazol-3(2H)-one 1,1-dioxide
Reaction equation
Cl[C:2]1[C:3](=[O:21])[N:4]([CH2:19][CH3:20])[S:5](=[O:18])(=[O:17])[C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1.[N:22]1([C:28]2[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=2)[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[CH2:19]([N:4]1[C:3](=[O:21])[C:2]([NH:32][C:31]2[CH:30]=[CH:29][C:28]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[CH:34][CH:33]=2)=[C:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[S:5]1(=[O:18])=[O:17])[CH3:20]Participants
3
Procedure
The title compound was prepared from 4-chloro-2-ethyl-5-[4-(trifluoromethyl)phenyl]isothiazol-3(2H)-one 1,1-dioxide and 4-morpholin-4-ylaniline in a similar manner as described for Example 11. 1H NMR (500 MHz, CDCl3): δ 1.51 (t, 3H), 2.98-3.01 (m, 4H), 3.81-3.83 (m, 4H), 3.88 (q, 2H), 6.52 (d, 2H), 6.64 (d, 2H), 7.22 (d, 2H), 7.36 (d, 2H).
Sources & evidence
- ORD record
- ord-6e9ca3d2d8c8432db84820c6edf69555
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07582629B2
Reaction notes
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