反应详情

温度

25 °C

(5-Aminoindol-2-yl)methan-1-ol. Ethyl 5-aminoindole-2-carboxylate, Example 74(a), (1.5 g, 7.3 mmol) was transferred to a round-bottomed flask and treated with lithium aluminum hydride (10 mL, 10 mmol, 1.0 M in THF, Aldrich) under N2. The reaction mixture was magnetically stirred at 25° C. for 1 h, then quenched by the dropwise addition of H2O (0.5 mL) followed by 20% aq. KOH (30 mL). The suspension was filtered and the aqueous phase extracted with EtOAc. The organic extract was concentrated in vacuo. Purification of the crude product by silica gel chromatography (20:80 hexane:EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 163 (M+1).

1. customquenched by the dropwise addition of H2O (0.5 mL)
2. filtrationThe suspension was filtered
3. extractionthe aqueous phase extracted with EtOAc
4. extractionThe organic extract
5. concentrationwas concentrated in vacuo
6. customPurification of the crude product by silica gel chromatography (20:80 hexane:EtOAc)