反应详情

The title compound was prepared from [3-Methyl-4-(piperidin-4-yloxy)-phenyl]-(6-morpholin-4-yl-pyrido[3,4-d]pyrimidin-4-yl)-amine and cyclopentyl isocyanate by a procedure analogous to the synthesis of 4-[4-(6-Fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-piperidine-1-carboxylic acid (2,6-difluoro-phenyl)-amide above. LRMS: 532.3/421.3 (MH+); 1H NMR (DMSO-d6, 400 MHz): δ 9.57 (s, 1H), δ 8.78 (s, 1H), δ 8.32 (s, 1H), δ 7.48-7.54 (m, 3H), δ 7.12 (d, J=9.14 1H), δ 6.24 (d, J=7.30, 1H), δ 4.50-5.19 (m, 1H), δ 3.84-3.89 (m, 1H), δ 3.74-3.76 (m, 4H), δ 3.51-3.59 (m, 6H), δ 3.12-3.18 (m, 2H), δ 2.16 (s, 3H), δ 1.81-1.86 (m, 4H), δ 1.29-1.76 (m, 8H).